Inter-lab diff for lot B-0114: 99.4% vs 96.8%. Within expected range.
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#dosing-titration 2025-06-10
Tuesday41 messages11 participantstimes are UTC
Highlights from this day
- pbs_pip — how much does the last dose still matter 6 days later 18:40
- slow.taper — update from 12 months ago: held at the same dose the whole time and still losing slowly 19:22
- slow.taper — split dosing has no trial behind it. people here do it and report on it, thats all 19:32
- ferritin_fay — after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice 20:02
- ferritin_fay — i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat 20:25
anyone here split their weekly into two and would they do it again
i hold for two months minimum before i decide a dose has stopped doing anything
how much does the last dose still matter 6 days later
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgfollow up how do you tell a plateau from just being at your set point
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
i drifted from sunday to wednesday over a year and only noticed when i checked the log
i escalate on symptoms. if the current dose is still doing something i stay on it
appetite returning at the end of the week is extremely common and is not the dose failing
what does the room think about jumping a rung to catch up
update from 12 months ago: held at the same dose the whole time and still losing slowly
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split dosing has no trial behind it. people here do it and report on it, thats all
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pick a day and stick to it
i went from 1 to 15 and honestly could not tell the difference in appetite
thats noise
holding is not failing. most people here who lasted two years held at least one dose for months
[edited]i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
appetite returning at the end of the week is extremely common and is not the dose failing
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the people who do best here are almost always the ones going slowest
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)if you are asking whether to go up, the fact you are asking usually means not yet
held for months
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
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not advice
thats normal
my dose day has drifted 8 days later over 13 months, does it matter
while im here with a roughly seven day half-life you are near steady state after about five weeks at a dose, for what its worth
thats anecdote
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plateau versus set point is not answerable in under six months of data
small steps are better than big ones and the only reason people take big ones is impatience
the ladder in the trials is a starting point, not a schedule you owe anyone
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half life is a week
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the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
if i took it 3 days late do i shift the schedule or go back to the old day
if it "stopped working after four days" that is almost never pharmacokinetics
two weeks is nothing
if the current dose is still working, going up is spending headroom you might want later, your mileage will differ
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
end of week thing
unrelated but whats a sensible maintenance dose after a year at treatment dose