vialroom

#dosing-titration 2025-06-16

Monday18 messages5 participantstimes are UTC
Highlights from this day
  • ghent_gradient — update on the earlier thing after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice 11:41
  • yyz_vial — a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored 13:32
  • bea_reconstitutes — came down from a treatment dose to maintenance over about three months and it was uneventful 13:39
  • yyz_vial — my titration ladder took 26 months to climb and i would do it slower again 13:41
  • bea_reconstitutes — holding is not failing. most people here who lasted two years held at least one dose for months 13:43
GG

update on the earlier thing after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice

🤝2

i hold for two months minimum before i decide a dose has stopped doing anything

YV

a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored

😂11❤️1
BR

if the current dose is still working, going up is spending headroom you might want later

[edited]

came down from a treatment dose to maintenance over about three months and it was uneventful

Cited study
Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1)
New England Journal of Medicine · 2022
72 weeks, tirzepatide 5, 10 and 15mg against placebo.
YV

my titration ladder took 26 months to climb and i would do it slower again

📈17
BR

holding is not failing. most people here who lasted two years held at least one dose for months

[edited]
😂6

half life is a week

QH

i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat

HH

small steps are better than big ones and the only reason people take big ones is impatience

if it "stopped working after four days" that is almost never pharmacokinetics, i think

QH

how much does the last dose still matter 9 days later
i drifted from sunday to wednesday over a year and only noticed when i checked the log