go slower
#dosing-titration 2025-07-01
Tuesday44 messages8 participantstimes are UTC
Highlights from this day
- fibre_first — split dosing has no trial behind it. people here do it and report on it, thats all 10:12
- snac_and_water — update from 3 months ago: held at the same dose the whole time and still losing slowly, for what its worth 10:23
- LC_MS_Lena — stepping back down on purpose is a completely reasonable move and this channel should say so more often 11:08
- VialBot — Verification log updated: QYB — evidence added, status unchanged. 16:07
- hydrate_hana — whats the smallest step anyone has managed between doses 16:20
holding is not failing. most people here who lasted two years held at least one dose for months
held for months
split dosing has no trial behind it. people here do it and report on it, thats all
📈14🧊15👍12
plateau versus set point is not answerable in under six months of data
update from 3 months ago: held at the same dose the whole time and still losing slowly, for what its worth
📉17🔥6😂2
came down from a treatment dose to maintenance over about three months and it was uneventful
how do you tell a plateau from just being at your set point
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
is there any actual reason to escalate every 4 weeks other than the trial did it
i hold for two months minimum before i decide a dose has stopped doing anything
stepping back down on purpose is a completely reasonable move and this channel should say so more often
❤️15😂2👍13
i went from 7.5 to 12 and honestly could not tell the difference in appetite
the trials escalated on a fixed schedule because a trial has to. you are not a trial
Purity check: no report on file for lot F-1330. Nothing logged either way.
came down, no regrets
not advice
❤️1🤝8
thats normal
i drifted from sunday to wednesday over a year and only noticed when i checked the log, we shall see
i escalate on symptoms. if the current dose is still doing something i stay on it
what does the room think about jumping a rung to catch up
if you are asking whether to go up, the fact you are asking usually means not yet
[edited]whats your rule for when a side effect means hold rather than push
small steps are better than big ones and the only reason people take big ones is impatience, ymmv
my titration ladder took 20 months to climb and i would do it slower again, we shall see
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
coa-kp-0925.pdf
1 page · 860 KB · not retained in the public archive
the people who do best here are almost always the ones going slowest
the ladder in the trials is a starting point, not a schedule you owe anyone
the ladder in the trials is a starting point, not a schedule you owe anyone, ymmv
coming back to this i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
two weeks is nothing
[edited]with a roughly seven day half-life you are near steady state after about five weeks at a dose, thats just me
too early imo
⚠️9📈16
no trial for that
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
fridge-thermometer.png
800 × 800 · 579 KB · not retained in the public archive
🔥1👍1😂1
the honest answer is that most of us are running protocols nobody has ever studied
pick a day and stick to it
Verification log updated: QYB — evidence added, status unchanged.
👍4🧪4
i would hold
i escalate on symptoms. if the current dose is still doing something i stay on it
you do not have to escalate at all. that is a real option that gets forgotten
sorry to jump in nobody here can tell you what dose to be on and the ones who try get corrected
end of week thing
whats the smallest step anyone has managed between doses
🤝5🔥4🧪8
thats noise
📉4🔥2🧪1