anyone here split their weekly into two and would they do it again
#dosing-titration 2025-07-13
Sunday60 messages10 participantstimes are UTC
Highlights from this day
- tallinn_taper — for the archive dose day drift is mostly harmless with a weekly compound, but pick a day and defend it 16:29
- tallinn_taper — my titration ladder took 22 months to climb and i would do it slower again 16:56
- mira_pins — coming down from 0.25 to 5, how bad is the appetite rebound 16:58
- taper_tess — a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored 17:09
- no_escrow_nate — appetite returning at the end of the week is extremely common and is not the dose failing 18:16
split dosing has no trial behind it. people here do it and report on it, thats all, thats one data point
i escalate on symptoms. if the current dose is still doing something i stay on it
*PeptideMeter not the other one
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
while im here holding is not failing. most people here who lasted two years held at least one dose for months
with a roughly seven day half-life you are near steady state after about five weeks at a dose
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the ladder in the trials is a starting point, not a schedule you owe anyone
how do you decide between holding and stepping when both feel wrong
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
i drifted from sunday to wednesday over a year and only noticed when i checked the log, happy to be corrected
thats anecdote
held for months
thats noise
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n of 1
if you are going up because the scale stalled for two weeks, wait. two weeks is noise, n of 1 obviously
[edited]whats the smallest step anyone has managed between doses
go slower
i hold for two months minimum before i decide a dose has stopped doing anything
end of week thing
whats your rule for when a side effect means hold rather than push
is it normal for appetite to come back at the end of the week
for the archive dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
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right so plateau versus set point is not answerable in under six months of data, still working it out
small steps are better than big ones and the only reason people take big ones is impatience
steady state is 5 weeks
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nobody here can tell you what dose to be on and the ones who try get corrected
my titration ladder took 23 months to climb and i would do it slower again
my titration ladder took 22 months to climb and i would do it slower again
coa-a-2601.pdf
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coming down from 0.25 to 5, how bad is the appetite rebound
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a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
U-100 syringe: 1 unit = 0.01 ml
10u = 0.10 ml
25u = 0.25 ml
50u = 0.50 ml
100u = 1.00 ml
mg drawn = ml drawn x mg/mlwhats a sensible maintenance dose after a year at treatment dose
[edited]hold
too early imo
if it "stopped working after four days" that is almost never pharmacokinetics
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
is there a point where going up stops buying you anything
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i escalate on symptoms. if the current dose is still doing something i stay on it
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
if you are asking whether to go up, the fact you are asking usually means not yet, thats one data point
no trial for that
appetite returning at the end of the week is extremely common and is not the dose failing
genuine question do you escalate on the calendar or on how you feel
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
how long did you hold at 0.5 before you moved up
came down, no regrets
the trials escalated on a fixed schedule because a trial has to. you are not a trial
sorry to jump in is week 30 too early to be thinking about the next step
has anyone gone up and then straight back down and been glad they tried
update from 5 months ago: held at the same dose the whole time and still losing slowly, still working it out
the people who do best here are almost always the ones going slowest
i went up too fast and im paying for it, do i drop back or ride it out
i went from 2.4 to 12 and honestly could not tell the difference in appetite
[edited]is there any actual reason to escalate every 4 weeks other than the trial did it
for the archive if i took it 4 days late do i shift the schedule or go back to the old day
not advice
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do you tell your prescriber you held or do you just hold
sorry to jump in came down from a treatment dose to maintenance over about three months and it was uneventful
[edited]stepping back down on purpose is a completely reasonable move and this channel should say so more often
i would hold
if you are going up because the scale stalled for two weeks, wait. two weeks is noise