vialroom

#dosing-titration 2025-07-23

Wednesday51 messages10 participantstimes are UTC
Highlights from this day
  • VialBot — Verification log updated: QYB — evidence added, status unchanged. 18:44
  • u100_pat — stepping back down on purpose is a completely reasonable move and this channel should say so more often 19:13
  • van_isle_vial — the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess 19:28
  • VialBot — Verification log updated: GL Biochem — evidence added, status unchanged. 19:29
  • stack_sceptic — whats the smallest step anyone has managed between doses 20:11
MG

no trial for that

Cited study
Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1)
New England Journal of Medicine · 2022
72 weeks, tirzepatide 5, 10 and 15mg against placebo.

*that should say weekly

VB

Verification log updated: QYB — evidence added, status unchanged.

KF

the honest answer is that most of us are running protocols nobody has ever studied

KF

follow up you do not have to escalate at all. that is a real option that gets forgotten, your mileage will differ

NW

small steps are better than big ones and the only reason people take big ones is impatience

U1

stepping back down on purpose is a completely reasonable move and this channel should say so more often

💀8🎉14🧪1
U1

is there a trial anywhere that studied twice weekly, or is it all anecdote

VB

Verification log updated: GL Biochem — evidence added, status unchanged.

quick one update question: did anyone who held for 7 months regret it

i have been at 10 for 23 months and honestly i have stopped wanting to move

i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat

SD

i went from 0.5 to 5 and honestly could not tell the difference in appetite

SS

anyone here split their weekly into two and would they do it again
the trials escalated on a fixed schedule because a trial has to. you are not a trial

came down, no regrets

the ladder in the trials is a starting point, not a schedule you owe anyone, not advice obviously

with a roughly seven day half-life you are near steady state after about five weeks at a dose

TO

i escalate on symptoms. if the current dose is still doing something i stay on it

TO

if the current dose is still working, going up is spending headroom you might want later, happy to be corrected

half life is a week

👀2⚠️9

whats a sensible maintenance dose after a year at treatment dose
update from 11 months ago: held at the same dose the whole time and still losing slowly

MG

my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, take that with a pinch of salt

ST

right so i log dose, day, weight and one line about how the week felt. thats enough to make decisions on

ST

the people who do best here are almost always the ones going slowest
holding is not failing. most people here who lasted two years held at least one dose for months

holding is not failing. most people here who lasted two years held at least one dose for months

update from 9 months ago: held at the same dose the whole time and still losing slowly

ST

if you are asking whether to go up, the fact you are asking usually means not yet

dose day drift is mostly harmless with a weekly compound, but pick a day and defend it

how do you decide between holding and stepping when both feel wrong

held for months