thats normal
#dosing-titration 2025-08-10
Sunday47 messages9 participantstimes are UTC
Highlights from this day
- tokyo_taper — sorry to jump in plateau versus set point is not answerable in under six months of data 10:44
- warsaw_vial — whats your rule for when a side effect means hold rather than push 13:38
- bac_water_bill — appetite returning at the end of the week is extremely common and is not the dose failing 14:18
- half_life_hal — dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, ask me again in a month 16:33
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored, thats one data point
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
i have been at 7.5 for 6 months and honestly i have stopped wanting to move
stepping back down on purpose is a completely reasonable move and this channel should say so more often
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice, i have it written down somewhere
do you tell your prescriber you held or do you just hold
[redacted at member request] · archive policy
the people who do best here are almost always the ones going slowest
follow up the ladder in the trials is a starting point, not a schedule you owe anyone
i drifted from sunday to wednesday over a year and only noticed when i checked the log
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if you are going up because the scale stalled for two weeks, wait. two weeks is noise
sorry to jump in plateau versus set point is not answerable in under six months of data
if you are asking whether to go up, the fact you are asking usually means not yet
anyone tracked whether a smaller more frequent dose changed their side effects
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, i have it written down somewhere
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
if i hold at 1 indefinitely am i losing anything
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i hold for two months minimum before i decide a dose has stopped doing anything
whats the longest anyone has stayed on one dose
is there a trial anywhere that studied twice weekly, or is it all anecdote
go slower
thats anecdote
pick a day and stick to it
how do you tell a plateau from just being at your set point
unrelated but i went from 1.7 to 7.5 and honestly could not tell the difference in appetite
whats your rule for when a side effect means hold rather than push
lot-log.csv
574 rows · not retained in the public archive
thats noise
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i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
appetite returning at the end of the week is extremely common and is not the dose failing
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my dose day has drifted 2 days later over 20 months, does it matter
split dosing has no trial behind it. people here do it and report on it, thats all
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i would hold
held for months
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my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
quick one coming down from 1 to 5, how bad is the appetite rebound
if it "stopped working after four days" that is almost never pharmacokinetics
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else, thats just me
is there a point where going up stops buying you anything
update from 18 months ago: held at the same dose the whole time and still losing slowly
small steps are better than big ones and the only reason people take big ones is impatience
slightly off topic but update from 26 months ago: held at the same dose the whole time and still losing slowly
half life is a week
came down, no regrets
for the archive update question: did anyone who held for 4 months regret it
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coming back to this my titration ladder took 14 months to climb and i would do it slower again
two weeks is nothing
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, ask me again in a month
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