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#dosing-titration 2025-08-16

Saturday15 messages4 participantstimes are UTC
Highlights from this day
  • gus_charts — i escalate on symptoms. if the current dose is still doing something i stay on it 21:11
  • gus_charts — do you tell your prescriber you held or do you just hold i went from 0.5 to 1 and honestly could not tell the difference in appetite 21:34
  • brisbane_bac — i went from 12 to 0.25 and honestly could not tell the difference in appetite 22:12
  • VialBot — Channel stats, last 30 days: 131 messages from 46 members. 22:59
GC

i escalate on symptoms. if the current dose is still doing something i stay on it

Cited study
Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1)
New England Journal of Medicine · 2021
68 weeks, semaglutide 2.4mg weekly against placebo, with lifestyle intervention in both arms.
GC

do you tell your prescriber you held or do you just hold
i went from 0.5 to 1 and honestly could not tell the difference in appetite

[edited]
TM

whats a sensible maintenance dose after a year at treatment dose

BB

i went from 12 to 0.25 and honestly could not tell the difference in appetite

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sorry to jump in coming down from 5 to 1.7, how bad is the appetite rebound

TM

dose day drift is mostly harmless with a weekly compound, but pick a day and defend it

is there a trial anywhere that studied twice weekly, or is it all anecdote

anyone here split their weekly into two and would they do it again

BB

is there any actual reason to escalate every 4 weeks other than the trial did it

VB

Channel stats, last 30 days: 131 messages from 46 members.

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