dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
#dosing-titration 2025-08-23
Saturday28 messages5 participantstimes are UTC
Highlights from this day
- warsaw_vial — how long did you hold at 2.5 before you moved up 12:45
- warsaw_vial — what does the room think about jumping a rung to catch up 13:16
- typosquat_tay — my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step 13:37
- typosquat_tay — split dosing has no trial behind it. people here do it and report on it, thats all if you are going up because the scale stalled for two weeks, wait. two weeks is noise 17:42
how long did you hold at 2.5 before you moved up
👍17
the trials escalated on a fixed schedule because a trial has to. you are not a trial
came down from a treatment dose to maintenance over about three months and it was uneventful, i have it written down somewhere
what does the room think about jumping a rung to catch up
📉3💀5
is there any actual reason to escalate every 4 weeks other than the trial did it
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
small steps are better than big ones and the only reason people take big ones is impatience
if i hold at 2.5 indefinitely am i losing anything
n of 1
my titration ladder took 5 months to climb and i would do it slower again
end of week thing
🧪2🧊1
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
i hold for two months minimum before i decide a dose has stopped doing anything
is there a trial anywhere that studied twice weekly, or is it all anecdote
if you are asking whether to go up, the fact you are asking usually means not yet
how do you decide between holding and stepping when both feel wrong
you do not have to escalate at all. that is a real option that gets forgotten
came down, no regrets
steady state is 5 weeks
update from 7 months ago: held at the same dose the whole time and still losing slowly, thats one data point
too early imo
the honest answer is that most of us are running protocols nobody has ever studied
whats the smallest step anyone has managed between doses
the people who do best here are almost always the ones going slowest
hold
🙏15🧊1
split dosing has no trial behind it. people here do it and report on it, thats all
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
is week 2 too early to be thinking about the next step
quick one update question: did anyone who held for 19 months regret it