what does the room think about jumping a rung to catch up
#dosing-titration 2025-09-30
Tuesday53 messages12 participantstimes are UTC
Highlights from this day
holding is not failing. most people here who lasted two years held at least one dose for months
the ladder in the trials is a starting point, not a schedule you owe anyone, i have it written down somewhere
if i took it 2 days late do i shift the schedule or go back to the old day
coming back to this i hold for two months minimum before i decide a dose has stopped doing anything, still working it out
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, anyway
stepping back down on purpose is a completely reasonable move and this channel should say so more often
my dose day has drifted 2 days later over 6 months, does it matter
with a roughly seven day half-life you are near steady state after about five weeks at a dose
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
whats the longest anyone has stayed on one dose
[edited]i drifted from sunday to wednesday over a year and only noticed when i checked the log
is there any actual reason to escalate every 4 weeks other than the trial did it
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a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
not advice
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is it normal for appetite to come back at the end of the week
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, we shall see
the people who do best here are almost always the ones going slowest
Archive lookup: ring_size_down first appears in this channel on 2025-05-16.
no trial for that
two weeks is nothing
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plateau versus set point is not answerable in under six months of data
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
is week 21 too early to be thinking about the next step
the trials escalated on a fixed schedule because a trial has to. you are not a trial
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
my titration ladder took 13 months to climb and i would do it slower again, ymmv
nobody here can tell you what dose to be on and the ones who try get corrected
how long did you hold at 7.5 before you moved up
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
if it "stopped working after four days" that is almost never pharmacokinetics
came down, no regrets
if i hold at 2.4 indefinitely am i losing anything
whats your rule for when a side effect means hold rather than push
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whats a sensible maintenance dose after a year at treatment dose
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sorry to jump in whats the smallest step anyone has managed between doses
steady state is 5 weeks
i went up too fast and im paying for it, do i drop back or ride it out
update from 7 months ago: held at the same dose the whole time and still losing slowly, not advice obviously
anyone tracked whether a smaller more frequent dose changed their side effects
i have been at 1.7 for 14 months and honestly i have stopped wanting to move
small steps are better than big ones and the only reason people take big ones is impatience
pick a day and stick to it
do you escalate on the calendar or on how you feel
if you are going up because the scale stalled for two weeks, wait. two weeks is noise, i think
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update question: did anyone who held for 26 months regret it
came down from a treatment dose to maintenance over about three months and it was uneventful
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right so small steps are better than big ones and the only reason people take big ones is impatience
half life is a week
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how do you tell a plateau from just being at your set point
i would hold
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how much does the last dose still matter 2 days later
*VendorInvestigate not the other one