#dosing-titration 2025-10-04

Saturday24 messages7 participantstimes are UTC

Highlights from this day

area_percent — stepping back down on purpose is a completely reasonable move and this channel should say so more often, ill dig out the number 14:46
nhs_pathway_nell — whats the longest anyone has stayed on one dose 17:13
seven_five_sweet — whats the smallest step anyone has managed between doses i drifted from sunday to wednesday over a year and only noticed when i checked the log 18:32
VialBot — Purity check: no report on file for lot KP-0925. Nothing logged either way. 18:44
ten_of_ten — you do not have to escalate at all. that is a real option that gets forgotten 18:46

pinch_not_stretch 13:39

i hold for two months minimum before i decide a dose has stopped doing anything

seven_five_sweet 13:42

anyone tracked whether a smaller more frequent dose changed their side effects

marrow.modmod13:45

holding is not failing. most people here who lasted two years held at least one dose for months, happy to be corrected

marrow.modmod14:14

two weeks is nothing

Cited study

Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial

New England Journal of Medicine · 2023

48 weeks, dose-ranging. A Phase 2 result is not a safety record.

😂17👀4💀13

seven_five_sweet 14:16

hold

area_percentlab14:46

stepping back down on purpose is a completely reasonable move and this channel should say so more often, ill dig out the number

seven_five_sweet 14:49

held for months

pinch_not_stretch 15:21

right so nobody here can tell you what dose to be on and the ones who try get corrected

seven_five_sweet 15:31

the people who do best here are almost always the ones going slowest

pinch_not_stretch 15:42

how much does the last dose still matter 6 days later

pinch_not_stretch 16:17

how do you tell a plateau from just being at your set point

area_percentlab16:18

if it "stopped working after four days" that is almost never pharmacokinetics

what does the room think about jumping a rung to catch up

pinch_not_stretch i hold for two months minimum before i decide a dose has stopped doing anything

area_percentlab16:21

quick one small steps are better than big ones and the only reason people take big ones is impatience

seven_five_sweet 16:50

came down, no regrets

area_percentlab17:11

go slower

nhs_pathway_nell 17:13

whats the longest anyone has stayed on one dose

wk 1-4    2.5mg
wk 5-8    5.0mg
wk 9-20   7.5mg   <- stayed here
wk 21-24  10.0mg  (no extra benefit for me)
wk 25+    7.5mg   (came back down)

nhs_pathway_nell 17:27

if you are asking whether to go up, the fact you are asking usually means not yet

seven_five_sweet 18:32

whats the smallest step anyone has managed between doses
i drifted from sunday to wednesday over a year and only noticed when i checked the log

VialBotbot18:44

Purity check: no report on file for lot KP-0925. Nothing logged either way.

ten_of_ten 18:46

you do not have to escalate at all. that is a real option that gets forgotten

📉2🙏8

appetite returning at the end of the week is extremely common and is not the dose failing

slightly off topic but dose day drift is mostly harmless with a weekly compound, but pick a day and defend it

i went up too fast and im paying for it, do i drop back or ride it out