came down from a treatment dose to maintenance over about three months and it was uneventful
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#dosing-titration 2025-10-10
Friday31 messages8 participantstimes are UTC
Highlights from this day
- step_one_sian — do you escalate on the calendar or on how you feel 18:52
- dublin_dose — i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else 19:09
- per_mg_pete — for the archive i went from 0.25 to 2.5 and honestly could not tell the difference in appetite 20:24
how do you tell a plateau from just being at your set point
thats anecdote
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Verification log updated: QST — evidence added, status unchanged.
do you escalate on the calendar or on how you feel
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two weeks is nothing
held for months
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slightly off topic but if it "stopped working after four days" that is almost never pharmacokinetics
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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the trials escalated on a fixed schedule because a trial has to. you are not a trial
coming back to this if the current dose is still working, going up is spending headroom you might want later
came down, no regrets
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right so anyone here split their weekly into two and would they do it again
end of week thing
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do you count from injection day or from when you actually felt it
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too early imo
for the archive i went from 0.25 to 2.5 and honestly could not tell the difference in appetite
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dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
*week 21 not week 8
is there a trial anywhere that studied twice weekly, or is it all anecdote
i have been at 12 for 11 months and honestly i have stopped wanting to move
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
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coming back to this with a roughly seven day half-life you are near steady state after about five weeks at a dose
if you are asking whether to go up, the fact you are asking usually means not yet
holding is not failing. most people here who lasted two years held at least one dose for months
update on the earlier thing is it normal for appetite to come back at the end of the week
has anyone gone up and then straight back down and been glad they tried
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the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, ill dig out the number
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