is there a point where going up stops buying you anything
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#dosing-titration 2025-10-13
Monday13 messages4 participantstimes are UTC
Highlights from this day
- no_escrow_nate — i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else update from 13 months ago: held at the same… 18:46
- cold_pack_carla — do you tell your prescriber you held or do you just hold 19:21
- no_escrow_nate — a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored, take that with a pinch of salt 19:25
- triple_ag_tom — sorry to jump in after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice i hold for two months minimum before i decide a… 19:47
anyone here split their weekly into two and would they do it again
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
update from 13 months ago: held at the same dose the whole time and still losing slowly
the honest answer is that most of us are running protocols nobody has ever studied
do you tell your prescriber you held or do you just hold
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dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, n of 1 obviously
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored, take that with a pinch of salt
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is week 4 too early to be thinking about the next step
came down from a treatment dose to maintenance over about three months and it was uneventful, from memory
i escalate on symptoms. if the current dose is still doing something i stay on it
unrelated but if it "stopped working after four days" that is almost never pharmacokinetics
half life is a week
sorry to jump in after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
i hold for two months minimum before i decide a dose has stopped doing anything