stepping back down on purpose is a completely reasonable move and this channel should say so more often, your mileage will differ
#dosing-titration 2025-10-27
Monday23 messages4 participantstimes are UTC
Highlights from this day
- hiccup_hollis — is it normal for appetite to come back at the end of the week 19:47
- hard_stop_hal — split dosing has no trial behind it. people here do it and report on it, thats all 20:02
- one_variable — small steps are better than big ones and the only reason people take big ones is impatience 20:36
- one_variable — i log dose, day, weight and one line about how the week felt. thats enough to make decisions on the argument for splitting is a flatter curve. the argument against is… 20:55
- one_variable — anyone tracked whether a smaller more frequent dose changed their side effects 21:05
do you count from injection day or from when you actually felt it
two weeks is nothing
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
is it normal for appetite to come back at the end of the week
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coming back to this is week 8 too early to be thinking about the next step
split dosing has no trial behind it. people here do it and report on it, thats all
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appetite returning at the end of the week is extremely common and is not the dose failing
the ladder in the trials is a starting point, not a schedule you owe anyone, thats one data point
while im here my titration ladder took 9 months to climb and i would do it slower again
slightly off topic but with a roughly seven day half-life you are near steady state after about five weeks at a dose
[edited]steady state is 5 weeks
the people who do best here are almost always the ones going slowest
end of week thing
has anyone gone up and then straight back down and been glad they tried
small steps are better than big ones and the only reason people take big ones is impatience
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i drifted from sunday to wednesday over a year and only noticed when i checked the log
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
anyone tracked whether a smaller more frequent dose changed their side effects
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holding is not failing. most people here who lasted two years held at least one dose for months
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
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dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
while im here came down from a treatment dose to maintenance over about three months and it was uneventful