while im here i drifted from sunday to wednesday over a year and only noticed when i checked the log, thats one data point
#dosing-titration 2025-11-14
Friday41 messages11 participantstimes are UTC
Highlights from this day
- calgary_cold — i went up too fast and im paying for it, do i drop back or ride it out 09:59
- tesa_tess — dose day drift is mostly harmless with a weekly compound, but pick a day and defend it 10:13
- tesa_tess — while im here i went from 2.4 to 2.5 and honestly could not tell the difference in appetite 10:16
- half_life_hal — with a roughly seven day half-life you are near steady state after about five weeks at a dose 12:18
- calgary_cold — i have been at 7.5 for 4 months and honestly i have stopped wanting to move 17:16
sorry to jump in if it "stopped working after four days" that is almost never pharmacokinetics
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the ladder in the trials is a starting point, not a schedule you owe anyone
steady state is 5 weeks
the honest answer is that most of us are running protocols nobody has ever studied
thats anecdote
you do not have to escalate at all. that is a real option that gets forgotten
i went up too fast and im paying for it, do i drop back or ride it out
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgdose day drift is mostly harmless with a weekly compound, but pick a day and defend it
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while im here i went from 2.4 to 2.5 and honestly could not tell the difference in appetite
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)the trials escalated on a fixed schedule because a trial has to. you are not a trial, anyway
whats a sensible maintenance dose after a year at treatment dose
i went from 1 to 10 and honestly could not tell the difference in appetite
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i would hold
update from 7 months ago: held at the same dose the whole time and still losing slowly
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no trial for that
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has anyone gone up and then straight back down and been glad they tried
nobody here can tell you what dose to be on and the ones who try get corrected
half life is a week
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
i hold for two months minimum before i decide a dose has stopped doing anything
if the current dose is still working, going up is spending headroom you might want later
with a roughly seven day half-life you are near steady state after about five weeks at a dose
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if you are going up because the scale stalled for two weeks, wait. two weeks is noise, not advice obviously
end of week thing
is there any actual reason to escalate every 4 weeks other than the trial did it
the people who do best here are almost always the ones going slowest
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whats the smallest step anyone has managed between doses
is there a trial anywhere that studied twice weekly, or is it all anecdote
two weeks is nothing
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sorry to jump in the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
is there a point where going up stops buying you anything
quick one my titration ladder took 4 months to climb and i would do it slower again
does a missed week reset anything or do you just carry on
came down, no regrets
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hold
do you count from injection day or from when you actually felt it
plateau versus set point is not answerable in under six months of data
thats noise
too early imo
i have been at 7.5 for 4 months and honestly i have stopped wanting to move
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