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#dosing-titration 2025-11-21

Friday27 messages8 participantstimes are UTC
Highlights from this day
  • VialBot — Assay note: BCH lot SG-1177 reported at 99.2% of label content. 17:01
  • quill_questions — split dosing has no trial behind it. people here do it and report on it, thats all 17:34
  • slow.taper — update from 25 months ago: held at the same dose the whole time and still losing slowly split dosing has no trial behind it. people here do it and report on it, thats… 17:39
  • slow.taper — i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else 18:08
ST

right so the trials escalated on a fixed schedule because a trial has to. you are not a trial

VB

Assay note: BCH lot SG-1177 reported at 99.2% of label content.

U1

my titration ladder took 13 months to climb and i would do it slower again

ST

if you are asking whether to go up, the fact you are asking usually means not yet

[edited]
QQ

ok so i have been at 5 for 14 months and honestly i have stopped wanting to move

i would hold

Trial scheduleWhat most people here do
Step interval4 weeks, fixed4-12 weeks, on symptoms
Holdingprotocol deviationnormal and expected
Top dosereached by designoften never reached
Coming downnot studiedcommon at maintenance
ST

i drifted from sunday to wednesday over a year and only noticed when i checked the log

QQ

split dosing has no trial behind it. people here do it and report on it, thats all

Trial scheduleWhat most people here do
Step interval4 weeks, fixed4-12 weeks, on symptoms
Holdingprotocol deviationnormal and expected
Top dosereached by designoften never reached
Coming downnot studiedcommon at maintenance

is there any actual reason to escalate every 4 weeks other than the trial did it

ST

update from 25 months ago: held at the same dose the whole time and still losing slowly
split dosing has no trial behind it. people here do it and report on it, thats all

💀3🧪1

i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat, i think

dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, happy to be corrected

QQ

if i took it 5 days late do i shift the schedule or go back to the old day

[edited]

how long did you hold at 2.5 before you moved up

half life is a week

EO

plateau versus set point is not answerable in under six months of data, take that with a pinch of salt