#dosing-titration 2025-12-01

Monday20 messages4 participantstimes are UTC

Highlights from this day

first_and_last_four — dose day drift is mostly harmless with a weekly compound, but pick a day and defend it 19:00
first_and_last_four — do you tell your prescriber you held or do you just hold 19:31
batch_bandit — nobody here can tell you what dose to be on and the ones who try get corrected 19:36
tess_tirz — a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored, n of 1 obviously 19:37
tess_tirz — if it "stopped working after four days" that is almost never pharmacokinetics 20:08

with a roughly seven day half-life you are near steady state after about five weeks at a dose

while im here i escalate on symptoms. if the current dose is still doing something i stay on it

whats your rule for when a side effect means hold rather than push

dose day drift is mostly harmless with a weekly compound, but pick a day and defend it

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thats noise

do you tell your prescriber you held or do you just hold

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n of 1

held for months

nobody here can tell you what dose to be on and the ones who try get corrected

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a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored, n of 1 obviously

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thats anecdote

small steps are better than big ones and the only reason people take big ones is impatience

if it "stopped working after four days" that is almost never pharmacokinetics

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two weeks is nothing

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anyone tracked whether a smaller more frequent dose changed their side effects

end of week thing

i went from 1 to 7.5 and honestly could not tell the difference in appetite, someone check my working

stepping back down on purpose is a completely reasonable move and this channel should say so more often

do you escalate on the calendar or on how you feel

[edited]

the people who do best here are almost always the ones going slowest
nobody here can tell you what dose to be on and the ones who try get corrected