vialroom

#dosing-titration 2025-12-16

Tuesday30 messages5 participantstimes are UTC
Highlights from this day
  • meniscus_mel — update on the earlier thing i went from 1 to 7.5 and honestly could not tell the difference in appetite 18:21
  • turnaround_tam — my titration ladder took 22 months to climb and i would do it slower again 19:16
  • madrid_mg — came down from a treatment dose to maintenance over about three months and it was uneventful, someone check my working 19:44
  • madrid_mg — how do you decide between holding and stepping when both feel wrong 19:51
  • motivation_gone — does a missed week reset anything or do you just carry on a missed week does not reset you, but going straight back to the top dose after a gap is how people get… 20:46
MM

update on the earlier thing i went from 1 to 7.5 and honestly could not tell the difference in appetite

🤝3👀8

thats noise

TT

anyone here split their weekly into two and would they do it again

TT

the people who do best here are almost always the ones going slowest

my titration ladder took 22 months to climb and i would do it slower again

🔥1🧊1👍6

plateau versus set point is not answerable in under six months of data, i could be wrong

19:20marrow.mod pinned a message to this channel
MM

if you are going up because the scale stalled for two weeks, wait. two weeks is noise

half life is a week

TT

ok so update question: did anyone who held for 5 months regret it
i went from 12 to 1.7 and honestly could not tell the difference in appetite

[edited]
MM

came down from a treatment dose to maintenance over about three months and it was uneventful, someone check my working

🤝51💀2
MM

how do you decide between holding and stepping when both feel wrong

Cited study
Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
New England Journal of Medicine · 2023
48 weeks, dose-ranging. A Phase 2 result is not a safety record.
🙏142

you do not have to escalate at all. that is a real option that gets forgotten

MG

holding is not failing. most people here who lasted two years held at least one dose for months

not advice

i log dose, day, weight and one line about how the week felt. thats enough to make decisions on

😂2

i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat, ask me again in a month

whats the longest anyone has stayed on one dose

MM

follow up whats your rule for when a side effect means hold rather than push

MG

split dosing has no trial behind it. people here do it and report on it, thats all

does a missed week reset anything or do you just carry on
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored

go slower

peptidemeter-summary-h-2814.pdf
2 pages · 226 KB · not retained in the public archive

appetite returning at the end of the week is extremely common and is not the dose failing