vialroom

#dosing-titration 2026-01-11

Sunday19 messages6 participantstimes are UTC
Highlights from this day
  • slow.taper — the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess 19:56
  • slow.taper — if the current dose is still working, going up is spending headroom you might want later 20:06
  • pia_plateaus — i drifted from sunday to wednesday over a year and only noticed when i checked the log 20:32
  • subq_sy — update on the earlier thing stepping back down on purpose is a completely reasonable move and this channel should say so more often, ymmv plateau versus set point is… 20:34
WW

the honest answer is that most of us are running protocols nobody has ever studied

pick a day and stick to it

💀15🤝14⚠️17
SS

the trials escalated on a fixed schedule because a trial has to. you are not a trial

i went up too fast and im paying for it, do i drop back or ride it out

my titration ladder took 2 months to climb and i would do it slower again, take that with a pinch of salt

ST

the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess

ST

my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step

ST

if the current dose is still working, going up is spending headroom you might want later

Cited study
Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1)
New England Journal of Medicine · 2022
72 weeks, tirzepatide 5, 10 and 15mg against placebo.
PP

i drifted from sunday to wednesday over a year and only noticed when i checked the log

📉16🔥3
SS

update on the earlier thing stepping back down on purpose is a completely reasonable move and this channel should say so more often, ymmv
plateau versus set point is not answerable in under six months of data

ST

whats a sensible maintenance dose after a year at treatment dose

ST

i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat

PP

i hold for two months minimum before i decide a dose has stopped doing anything