steady state is 5 weeks
#dosing-titration 2026-01-20
Tuesday56 messages13 participantstimes are UTC
Highlights from this day
- combo_cai — small steps are better than big ones and the only reason people take big ones is impatience 18:43
- septum_sal — quick one a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored 21:52
- maintenance_mo — the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, i could be wrong 22:40
n of 1
appetite returning at the end of the week is extremely common and is not the dose failing
thats normal
nobody here can tell you what dose to be on and the ones who try get corrected
Recon calculator: 5mg in 5ml = 5mg/ml.
thats noise
update from 5 months ago: held at the same dose the whole time and still losing slowly
small steps are better than big ones and the only reason people take big ones is impatience
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i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
how do you decide between holding and stepping when both feel wrong
[edited]sorry to jump in you do not have to escalate at all. that is a real option that gets forgotten
two weeks is nothing
update question: did anyone who held for 7 months regret it
hold
my titration ladder took 5 months to climb and i would do it slower again
anyone here split their weekly into two and would they do it again
stepping back down on purpose is a completely reasonable move and this channel should say so more often
19:07marrow.mod pinned a message to this channel
whats your rule for when a side effect means hold rather than push
how long did you hold at 2 before you moved up
the people who do best here are almost always the ones going slowest
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has anyone gone up and then straight back down and been glad they tried
do you tell your prescriber you held or do you just hold
if it "stopped working after four days" that is almost never pharmacokinetics
do you escalate on the calendar or on how you feel
not advice
coming down from 1.7 to 0.5, how bad is the appetite rebound
i drifted from sunday to wednesday over a year and only noticed when i checked the log
split dosing has no trial behind it. people here do it and report on it, thats all
held for months
end of week thing
does a missed week reset anything or do you just carry on
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what does the room think about jumping a rung to catch up
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i went from 0.5 to 1.7 and honestly could not tell the difference in appetite
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is there a point where going up stops buying you anything
is there a trial anywhere that studied twice weekly, or is it all anecdote
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
Testing queue: 3 submissions open, 105 awaiting dispatch.
i escalate on symptoms. if the current dose is still doing something i stay on it
anyone tracked whether a smaller more frequent dose changed their side effects
i went up too fast and im paying for it, do i drop back or ride it out
is it normal for appetite to come back at the end of the week
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is there any actual reason to escalate every 4 weeks other than the trial did it
no trial for that
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, thats just me
thats anecdote
quick one a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
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if you are going up because the scale stalled for two weeks, wait. two weeks is noise
i would hold
came down, no regrets
how much does the last dose still matter 9 days later
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
came down from a treatment dose to maintenance over about three months and it was uneventful
how do you tell a plateau from just being at your set point
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, i could be wrong
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the honest answer is that most of us are running protocols nobody has ever studied
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