Inter-lab diff for lot A-2601: 98.6% vs 99%. Within expected range.
#dosing-titration 2026-02-14
Saturday25 messages7 participantstimes are UTC
Highlights from this day
- VialBot — Inter-lab diff for lot A-2601: 98.6% vs 99%. Within expected range. 23:00
- appetite_back — after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice, happy to be corrected 23:03
- u100_pat — if you are asking whether to go up, the fact you are asking usually means not yet 23:22
- u100_pat — i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else 23:28
while im here does a missed week reset anything or do you just carry on
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice, happy to be corrected
i hold for two months minimum before i decide a dose has stopped doing anything
if the current dose is still working, going up is spending headroom you might want later
whats your rule for when a side effect means hold rather than push
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
i escalate on symptoms. if the current dose is still doing something i stay on it
hold
has anyone gone up and then straight back down and been glad they tried
if you are asking whether to go up, the fact you are asking usually means not yet
coa-a-2418.pdf
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not advice
[edited]📉7
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
split dosing has no trial behind it. people here do it and report on it, thats all
update from 3 months ago: held at the same dose the whole time and still losing slowly
plateau versus set point is not answerable in under six months of data
do you escalate on the calendar or on how you feel
👍1
the honest answer is that most of us are running protocols nobody has ever studied, i could be wrong
is there a point where going up stops buying you anything
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat, happy to be corrected
snac_and_waterupdate from 3 months ago: held at the same dose the whole time and still losing slowly
quick one with a roughly seven day half-life you are near steady state after about five weeks at a dose
nobody here can tell you what dose to be on and the ones who try get corrected