if it "stopped working after four days" that is almost never pharmacokinetics
#dosing-titration 2026-02-27
Friday29 messages9 participantstimes are UTC
Highlights from this day
held for months
update question: did anyone who held for 1 months regret it
the honest answer is that most of us are running protocols nobody has ever studied, i think
nobody here can tell you what dose to be on and the ones who try get corrected
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quick one what does the room think about jumping a rung to catch up
plateau versus set point is not answerable in under six months of data
thats normal
not advice
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whats a sensible maintenance dose after a year at treatment dose
how long did you hold at 2 before you moved up
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
you do not have to escalate at all. that is a real option that gets forgotten
the people who do best here are almost always the ones going slowest, happy to be corrected
sorry to jump in how much does the last dose still matter 8 days later
steady state is 5 weeks
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n of 1
go slower
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i went up too fast and im paying for it, do i drop back or ride it out
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)🎉6⚠️2
Reminder for ten_of_ten: dose day is today. Set 5 days ago.
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two weeks is nothing
[edited]sorry to jump in is there a trial anywhere that studied twice weekly, or is it all anecdote
no trial for that
how do you tell a plateau from just being at your set point
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came down from a treatment dose to maintenance over about three months and it was uneventful, someone check my working
do you tell your prescriber you held or do you just hold