you do not have to escalate at all. that is a real option that gets forgotten
#dosing-titration 2026-03-11
Wednesday59 messages12 participantstimes are UTC
Highlights from this day
- vat_on_import — i drifted from sunday to wednesday over a year and only noticed when i checked the log 18:25
- tga_notice — my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step 19:25
- stack_sceptic — small steps are better than big ones and the only reason people take big ones is impatience 20:54
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
go slower
[edited]the ladder in the trials is a starting point, not a schedule you owe anyone
[edited]i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else, happy to be corrected
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too early imo
half life is a week
i hold for two months minimum before i decide a dose has stopped doing anything
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
how much does the last dose still matter 9 days later
not advice
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i would hold
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with a roughly seven day half-life you are near steady state after about five weeks at a dose
coming down from 2.4 to 0.25, how bad is the appetite rebound
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
how do you tell a plateau from just being at your set point
appetite returning at the end of the week is extremely common and is not the dose failing
i went from 15 to 0.25 and honestly could not tell the difference in appetite
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgupdate question: did anyone who held for 10 months regret it
my dose day has drifted 8 days later over 6 months, does it matter
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no trial for that
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i drifted from sunday to wednesday over a year and only noticed when i checked the log
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update from 25 months ago: held at the same dose the whole time and still losing slowly, still working it out
quick one whats your rule for when a side effect means hold rather than push
whats the longest anyone has stayed on one dose
is there a point where going up stops buying you anything
right so i escalate on symptoms. if the current dose is still doing something i stay on it
stepping back down on purpose is a completely reasonable move and this channel should say so more often
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do you escalate on the calendar or on how you feel
thats anecdote
is there a trial anywhere that studied twice weekly, or is it all anecdote
the people who do best here are almost always the ones going slowest
*that should say weekly
slightly off topic but a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
if i took it 6 days late do i shift the schedule or go back to the old day
anyone tracked whether a smaller more frequent dose changed their side effects
if it "stopped working after four days" that is almost never pharmacokinetics
for the archive how long did you hold at 1.7 before you moved up
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held for months
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
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my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
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steady state is 5 weeks, ymmv
if you are asking whether to go up, the fact you are asking usually means not yet
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whats a sensible maintenance dose after a year at treatment dose
for the archive came down from a treatment dose to maintenance over about three months and it was uneventful
my titration ladder took 16 months to climb and i would do it slower again
you do not have to escalate at all. that is a real option that gets forgotten
thats noise
sorry to jump in i went up too fast and im paying for it, do i drop back or ride it out
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whats the smallest step anyone has managed between doses
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
if the current dose is still working, going up is spending headroom you might want later
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small steps are better than big ones and the only reason people take big ones is impatience
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)came down, no regrets
anyone here split their weekly into two and would they do it again
nobody here can tell you what dose to be on and the ones who try get corrected
is week 15 too early to be thinking about the next step
if the current dose is still working, going up is spending headroom you might want later
chain_of_custodymy titration ladder took 16 months to climb and i would do it slower again you do not…
pick a day and stick to it
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored