i hold for two months minimum before i decide a dose has stopped doing anything
#dosing-titration 2026-03-30
Monday43 messages9 participantstimes are UTC
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go slower
the honest answer is that most of us are running protocols nobody has ever studied
holding is not failing. most people here who lasted two years held at least one dose for months, i have it written down somewhere
[edited]a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored, ill dig out the number
update on the earlier thing if the current dose is still working, going up is spending headroom you might want later
i have been at 0.25 for 21 months and honestly i have stopped wanting to move
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
thats noise
genuine question whats the longest anyone has stayed on one dose
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has anyone gone up and then straight back down and been glad they tried
stepping back down on purpose is a completely reasonable move and this channel should say so more often
plateau versus set point is not answerable in under six months of data
if it "stopped working after four days" that is almost never pharmacokinetics
hold
small steps are better than big ones and the only reason people take big ones is impatience
split dosing has no trial behind it. people here do it and report on it, thats all
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you do not have to escalate at all. that is a real option that gets forgotten
how much does the last dose still matter 3 days later
*Janoshik not the other one
right so with a roughly seven day half-life you are near steady state after about five weeks at a dose
the ladder in the trials is a starting point, not a schedule you owe anyone
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the trials escalated on a fixed schedule because a trial has to. you are not a trial
steady state is 5 weeks
do you count from injection day or from when you actually felt it
whats the smallest step anyone has managed between doses
is week 20 too early to be thinking about the next step
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i went from 7.5 to 0.25 and honestly could not tell the difference in appetite
anyone here split their weekly into two and would they do it again
too early imo
[edited]the people who do best here are almost always the ones going slowest
my dose day has drifted 7 days later over 26 months, does it matter
i drifted from sunday to wednesday over a year and only noticed when i checked the log
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Reminder for ghk_gia: dose day is today. Set 6 days ago.
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what does the room think about jumping a rung to catch up
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
is it normal for appetite to come back at the end of the week
adelaide_assayi drifted from sunday to wednesday over a year and only noticed when i checked the log
how long did you hold at 0.5 before you moved up
[edited]is there a trial anywhere that studied twice weekly, or is it all anecdote
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if you are asking whether to go up, the fact you are asking usually means not yet
half life is a week
whats a sensible maintenance dose after a year at treatment dose