do you tell your prescriber you held or do you just hold
#dosing-titration 2026-04-23
Thursday28 messages7 participantstimes are UTC
Highlights from this day
- triple_ag_tom — with a roughly seven day half-life you are near steady state after about five weeks at a dose 14:27
- patent_2026 — is there a point where going up stops buying you anything 15:05
- patent_2026 — my titration ladder took 9 months to climb and i would do it slower again 15:11
- VialBot — Purity check: no report on file for lot A-2601. Nothing logged either way. 15:12
- two_three_lifts — whats the longest anyone has stayed on one dose with a roughly seven day half-life you are near steady state after about five weeks at a dose 18:31
how much does the last dose still matter 5 days later
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
thats noise
is it normal for appetite to come back at the end of the week
end of week thing
i went from 1.7 to 15 and honestly could not tell the difference in appetite
my dose day has drifted 6 days later over 9 months, does it matter
hold
i went up too fast and im paying for it, do i drop back or ride it out
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
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with a roughly seven day half-life you are near steady state after about five weeks at a dose
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i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
how do you decide between holding and stepping when both feel wrong
two weeks is nothing
is there a point where going up stops buying you anything
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too early imo
n of 1
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the people who do best here are almost always the ones going slowest
my titration ladder took 9 months to climb and i would do it slower again
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Purity check: no report on file for lot A-2601. Nothing logged either way.
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the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, ask me again in a month
ok so holding is not failing. most people here who lasted two years held at least one dose for months
if the current dose is still working, going up is spending headroom you might want later
not advice
whats the longest anyone has stayed on one dose
with a roughly seven day half-life you are near steady state after about five weeks at a dose
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right so i escalate on symptoms. if the current dose is still doing something i stay on it, i think
i have been at 12 for 2 months and honestly i have stopped wanting to move