#dosing-titration 2026-05-01

i went from 1.7 to 15 and honestly could not tell the difference in appetite, your mileage will differ

how do you tell a plateau from just being at your set point

not advice

i went up too fast and im paying for it, do i drop back or ride it out

came down from a treatment dose to maintenance over about three months and it was uneventful

update from 25 months ago: held at the same dose the whole time and still losing slowly, i think

nobody here can tell you what dose to be on and the ones who try get corrected

pick a day and stick to it

whats the longest anyone has stayed on one dose

small steps are better than big ones and the only reason people take big ones is impatience

does a missed week reset anything or do you just carry on

*VendorInvestigate not the other one

i escalate on symptoms. if the current dose is still doing something i stay on it

after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice

Testing queue: 7 submissions open, 124 awaiting dispatch.

do you tell your prescriber you held or do you just hold

slightly off topic but with a roughly seven day half-life you are near steady state after about five weeks at a dose

came down, no regrets

if you are asking whether to go up, the fact you are asking usually means not yet

if the current dose is still working, going up is spending headroom you might want later, i think

i would hold

my titration ladder took 16 months to climb and i would do it slower again, your mileage will differ

do you escalate on the calendar or on how you feel

dose day drift is mostly harmless with a weekly compound, but pick a day and defend it

thats anecdote

plateau versus set point is not answerable in under six months of data

if i hold at 0.5 indefinitely am i losing anything

has anyone gone up and then straight back down and been glad they tried

split dosing has no trial behind it. people here do it and report on it, thats all