after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
#dosing-titration 2026-05-03
Sunday17 messages6 participantstimes are UTC
Highlights from this day
- nim_new — if the current dose is still working, going up is spending headroom you might want later 09:55
- VialBot — Verification log updated: KP — evidence added, status unchanged. 13:55
- clothes_size_cass — if it "stopped working after four days" that is almost never pharmacokinetics 13:58
- vale_vials — coming down from 10 to 2.5, how bad is the appetite rebound 14:05
- amylin_amy — i log dose, day, weight and one line about how the week felt. thats enough to make decisions on, thats one data point 14:41
two weeks is nothing
steady state is 5 weeks
no trial for that
the ladder in the trials is a starting point, not a schedule you owe anyone
[edited]dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
has anyone gone up and then straight back down and been glad they tried
whats your rule for when a side effect means hold rather than push
came down from a treatment dose to maintenance over about three months and it was uneventful
if the current dose is still working, going up is spending headroom you might want later
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thats normal
Verification log updated: KP — evidence added, status unchanged.
if it "stopped working after four days" that is almost never pharmacokinetics
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coming down from 10 to 2.5, how bad is the appetite rebound
do you tell your prescriber you held or do you just hold
how long did you hold at 2.4 before you moved up
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i log dose, day, weight and one line about how the week felt. thats enough to make decisions on, thats one data point