with a roughly seven day half-life you are near steady state after about five weeks at a dose
[edited]🤝11
#dosing-titration 2026-05-08
Friday29 messages7 participantstimes are UTC
Highlights from this day
- triple_ag_tom — with a roughly seven day half-life you are near steady state after about five weeks at a dose 17:55
- spreadsheet_stu — whats a sensible maintenance dose after a year at treatment dose small steps are better than big ones and the only reason people take big ones is impatience 18:04
- courier_vs_post — unrelated but the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, ask me again in a month 18:39
if you are asking whether to go up, the fact you are asking usually means not yet, thats just me
steady state is 5 weeks
end of week thing
n of 1
whats a sensible maintenance dose after a year at treatment dose
small steps are better than big ones and the only reason people take big ones is impatience
not advice
[edited]my titration ladder took 11 months to climb and i would do it slower again, for what its worth
ok so i went from 12 to 10 and honestly could not tell the difference in appetite
unrelated but the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, ask me again in a month
right so the honest answer is that most of us are running protocols nobody has ever studied
[edited]the trials escalated on a fixed schedule because a trial has to. you are not a trial
half life is a week
unrelated but nobody here can tell you what dose to be on and the ones who try get corrected
follow up whats your rule for when a side effect means hold rather than push
split dosing has no trial behind it. people here do it and report on it, thats all
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
✅1
my dose day has drifted 5 days later over 12 months, does it matter
you do not have to escalate at all. that is a real option that gets forgotten
holding is not failing. most people here who lasted two years held at least one dose for months, i could be wrong
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, still working it out
small steps are better than big ones and the only reason people take big ones is impatience
right so appetite returning at the end of the week is extremely common and is not the dose failing
anyone here split their weekly into two and would they do it again
go slower
too early imo
update question: did anyone who held for 5 months regret it
the trials escalated on a fixed schedule because a trial has to. you are not a trial
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored