the people who do best here are almost always the ones going slowest
#dosing-titration 2026-05-24
Sunday30 messages8 participantstimes are UTC
Highlights from this day
- meniscus_mel — stepping back down on purpose is a completely reasonable move and this channel should say so more often if you are going up because the scale stalled for two weeks,… 08:14
- lot_number_lou — i went from 10 to 2.5 and honestly could not tell the difference in appetite 09:31
- nausea_window — plateau versus set point is not answerable in under six months of data i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat 09:43
- myrrh_measures — is there any actual reason to escalate every 4 weeks other than the trial did it 12:30
- birch_bloods — does a missed week reset anything or do you just carry on 12:44
the honest answer is that most of us are running protocols nobody has ever studied
steady state is 5 weeks
appetite returning at the end of the week is extremely common and is not the dose failing
no trial for that
stepping back down on purpose is a completely reasonable move and this channel should say so more often
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
transit-times.csv
351 rows · not retained in the public archive
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whats the longest anyone has stayed on one dose
[edited]how much does the last dose still matter 5 days later
thats anecdote
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update from 3 months ago: held at the same dose the whole time and still losing slowly
has anyone gone up and then straight back down and been glad they tried
small steps are better than big ones and the only reason people take big ones is impatience
whats your rule for when a side effect means hold rather than push
i went from 10 to 2.5 and honestly could not tell the difference in appetite
U-100 syringe: 1 unit = 0.01 ml
10u = 0.10 ml
25u = 0.25 ml
50u = 0.50 ml
100u = 1.00 ml
mg drawn = ml drawn x mg/mli have been at 7.5 for 2 months and honestly i have stopped wanting to move
i would hold
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hold
plateau versus set point is not answerable in under six months of data
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
whats a sensible maintenance dose after a year at treatment dose
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
the trials escalated on a fixed schedule because a trial has to. you are not a trial
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not advice
is there any actual reason to escalate every 4 weeks other than the trial did it
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the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
does a missed week reset anything or do you just carry on
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*week 10 not week 2
update question: did anyone who held for 4 months regret it