about the escalation holding is not failing. most people here who lasted two years held at least one dose for months, that is one ladder out of many
splitting the weekly is a real thing people
Spun off from a message in #dosing-titration on 2026-03-05. 17 messages, 3 participants.
- vial_ledger — week 20 for me and splitting the weekly is a real thing people do and the evidence for it in here is entirely anecdotal 19:52
the people who do best here are almost always the ones going slowest
half steps are people improvising with the material they have, and they log it honestly, which is the part that matters
came down too
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, ask again in a month and i may say something else
you do not have to escalate at all. that is a real option that gets forgotten, ask someone qualified about yours
titration question steady state is roughly five half lives, so about five weeks with a weekly compound
this is what i meant, thats a symptom question
if the current dose is still working, going up is spending headroom you might want later, one persons ladder
a step is a decision, not a calendar entry. if the current one is working there is nothing to fix, from my written notes
if you cannot say what a step is supposed to achieve, that is a reason to wait, nothing here is medical advice
on the ladder thing again i held for 10 months in the middle and then climbed normally afterwards with no drama at all
i hold for two months minimum before i decide a dose has stopped doing anything, research use only material, not approved for human use
a day either side of dose day is noise. a week either side is a different schedule, give or take
evening, give it another fortnight
been meaning to say i kept a one line note each week and the pattern only became obvious three months in, ymmv
someone else will know, steady state is 5 weeks