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Thread · #dosing-titration · 2026-05-10

is there a trial anywhere that studied twice weekly

Spun off from a message in #dosing-titration on 2026-05-10. 13 messages, 5 participants.

The message this came from
  • fasting_insulin — is there a trial anywhere that studied twice weekly, or is it all anecdote, no rush 20:55
DE
deamidationlab20:57

is there any actual reason to escalate every 4 weeks other than the trial did it, no rush

DE
deamidationlab21:06

trial escalation schedules are designed around dropout rates, which is not the same problem you have, no medal for the top

DE
deamidationlab21:16

splitting the weekly is a real thing people do and the evidence for it in here is entirely anecdotal, still at 1

PM
per_mg_pete21:18

anyone split the weekly into two and notice a difference either way

DE
deamidationlab21:24

dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, no medal for the top

VO
vat_on_import21:41

steady state is roughly five half lives, so about five weeks with a weekly compound, my day drifted anyway

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