anyone split the weekly into two and notice

split dosing has no trial behind it. people here do it and report on it, thats all

holding update i came down from the top and stayed down and my numbers did not move much either way, one persons ladder

yep, end of week thing

titration question anyone here split their weekly into two and would they do it again

dose day drift is mostly harmless with a weekly compound, but pick a day and defend it

steady state is roughly five half lives, so about five weeks with a weekly compound, nothing dramatic either way

write the dates down

i told my prescriber before i held rather than afterwards and it made the next conversation much easier

thats noise

i hold for two months minimum before i decide a dose has stopped doing anything

stepping back down on purpose is a completely reasonable move and this channel should say so more often, i would do it slower again

following up from last month my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step

i went from 1 to 2 and honestly could not tell the difference in appetite, that was on the old ladder

with a roughly seven day half-life you are near steady state after about five weeks at a dose