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Thread · #hplc-massspec · 2026-03-28

retention time is a hint, not a fingerprint. two

Spun off from a message in #hplc-massspec on 2026-03-28. 13 messages, 5 participants.

The message this came from
  • dexa_or_bia — retention time is a hint, not a fingerprint. two different peptides can co-elute perfectly happily, ill dig out the number 21:41

a warm transit can put a visible degradant peak on a chromatogram. that is what 15 days at ambient does

🎉6
SS

how much sample does a lab actually need for identity as well as purity

MM

is there any point running a blank if the sample is the question

TT

retention time is a hint, not a fingerprint. two different peptides can co-elute perfectly happily

😂2
SS

i was wrong about tailing factor. it is usually the injection or the pH, not the column