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#maintenance 2025-10-15

Wednesday42 messages8 participantstimes are UTC
Highlights from this day
  • vienna_vial — im holding at 12 for maintenance and wondering whether i should be lower 17:46
  • travel_cooler — i think about it the way i think about my blood pressure tablet, and that framing helped me more than anything else 18:23
  • travel_cooler — SURMOUNT-OSA is the stopping one. weight came back on for most people once the drug stopped. that is the finding, not an opinion 18:44
  • travel_cooler — nobody here can tell you whether to stop. we can tell you what happened to us when we did 18:46

SURMOUNT-1 is the one where they stopped and it came back isnt it, has anyone read the actual numbers

two or three kilos up and down is normal fluctuation. ten is a different conversation, ymmv

coa-f-1330.pdf
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lower frequency maintenance is genuinely unstudied. anybody telling you it is proven is making that up, for what its worth

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dropping to a maintenance dose was uneventful for me and completely miserable for somebody i talk to weekly, ill dig out the number

anyone gone off entirely and stayed off successfully
i was wrong about maintenance being the easy part and i had said so loudly for a year beforehand

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FI

a 10mg vial at a 2mg maintenance dose is five weeks of doses, so my monthly cost roughly halved, ymmv

FI

i set a trigger weight instead of a target. if i cross it i go up a rung. that is my entire plan
i weigh weekly at maintenance rather than daily and my range is about two kilos either side

VL

i went to every ten days at a low dose and it held for me. n of 1, and i keep saying that out loud

VL

i was wrong about maintenance being the easy part and i had said so loudly for a year beforehand
appetite returning is not the drug failing, it is the drug doing less because you are taking less of it

TF

the muscle question is the one i wish i had taken seriously at month two instead of month twelve

VL

i tried to come down and could not hold it, went back to treatment dose, and stopped apologising for it

AB

there is no trial on every ten days or every fortnight. people here do it and report on it and that is all we have

QH

food noise coming back at a lower dose settled again after about four weeks for me, i could be wrong

VL

i came off for four months, put 84 back on, and came back. no drama in it, just numbers

quick one appetite returning is not the drug failing, it is the drug doing less because you are taking less of it

AB

i lift twice a week specifically because losing fast without it cost me more than i was willing to lose, ill dig out the number

AB

i stayed at treatment dose for four months past goal and then came down slowly. that order was right for me

VV

i weigh weekly at maintenance rather than daily and my range is about two kilos either side

still at maintenance

VV

im holding at 12 for maintenance and wondering whether i should be lower

Cited study
Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (SELECT)
New England Journal of Medicine · 2023
Hard cardiovascular endpoints in people with overweight or obesity and established disease.

there is no official maintenance dose. it is a thing we do because the alternative on the table was stopping

QH

right so the maintenance conversation barely existed in here two years ago and now it is half the channel, not advice obviously
protein went up during maintenance for me rather than down, which was completely counterintuitive

QH

how much protein were people eating at maintenance compared to while losing

how much regain did people get in the first 21 months after stopping

TC

i think about it the way i think about my blood pressure tablet, and that framing helped me more than anything else

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TC

coming back to this appetite came back over about three weeks after i reduced, not all at once, which is what i had braced for

genuine question the honest answer to is this forever is that nobody knows and the drug only works while you are taking it

SURMOUNT-OSA is the stopping one. weight came back on for most people once the drug stopped. that is the finding, not an opinion

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nobody here can tell you whether to stop. we can tell you what happened to us when we did

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