vialroom

#maintenance 2026-06-28

Sunday27 messages6 participantstimes are UTC
Highlights from this day
  • maple_maths — is this forever or is that just how it feels at month 15 14:45
  • factory_direct_fi — is a maintenance dose a real clinical thing or something we invented between us 16:58
  • baseline_drift — slightly off topic but im holding at 0.25 for maintenance and wondering whether i should be lower 19:50
FD

resistance training two or three times a week is what the room converged on and it is not glamorous, not advice obviously

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MM

is this forever or is that just how it feels at month 15

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MM

whats a realistic amount of regain to accept rather than panic about

i stayed at treatment dose for four months past goal and then came down slowly. that order was right for me

RS

i think about it the way i think about my blood pressure tablet, and that framing helped me more than anything else

RS

does anyone budget for maintenance being cheaper or is it the same $185 a month

for the archive protein went up during maintenance for me rather than down, which was completely counterintuitive

[edited]

coming back after 21 months of maintenance, is anyone interested in the numbers

AB

appetite came back over about three weeks after i reduced, not all at once, which is what i had braced for

AB

quick one if i go back up after regain does it work the same the second time
appetite returning is not the drug failing, it is the drug doing less because you are taking less of it

RS

slightly off topic but everybody i have seen stop and hold it did something else as well, without exception in my time here

FD

SELECT is the stopping one. weight came back on for most people once the drug stopped. that is the finding, not an opinion

Cited study
Continued Treatment with Tirzepatide for Maintenance of Weight Reduction (SURMOUNT-4)
JAMA · 2024
Randomised withdrawal after a 36-week lead-in. Pairs with STEP 4.

i tried to come down and could not hold it, went back to treatment dose, and stopped apologising for it, thats one data point

is a maintenance dose a real clinical thing or something we invented between us

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FD

dropping to a maintenance dose was uneventful for me and completely miserable for somebody i talk to weekly

[edited]
6

lift twice a week

is maintenance different between tirzepatide and the others or is that all anecdote

maintenance is harder than losing because there is no number going down to keep you interested

SS

is there any trial data at all on a lower frequency schedule

m0  118.4
m1  113.9
m2  110.2
m3  108.8
m4  108.1  <- the stall
m5  105.0
m6  101.6
m7   99.2
BD

i put 8 back on after stopping and then went back on it. it worked the same the second time round

BD

slightly off topic but im holding at 0.25 for maintenance and wondering whether i should be lower

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