#oral-glp1 2024-10-03

while im here the oral disappointed me on the mornings i couldnt manage 30 minutes fasted, which was most of them, ill dig out the number

is orforglipron a peptide at all

for the archive the oral mg number is bigger because almost none of it gets in, thats the entire reason, not advice obviously

about one percent

does the 30 minutes start from swallowing or from the water

how long before the oral did anything measurable for you

absorption is the variable, not the molecule. same tablet, different morning, different result

roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose

i use it because needles are a genuine problem for me, not because i think its better, thats one data point

ruined my breakfast

set a timer

coffee doesnt count

Digest for the week of 2024-04-27 has been published.

does coffee count as plain water, asking for obvious reasons

Purity check: no report on file for lot E-2205. Nothing logged either way.

PIONEER not OASIS

i do 6am with water and eat at 7, thats been my routine for 9 months

did anyone go back to injecting after trying oral

i was wrong about the water amount, i was using a sip and it needs a lot more than that

mine was patchy too

thirty minutes, no cheating

plain water only, about half a glass, then nothing for 30 minutes. i follow it exactly
PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses

why is the oral dose in mg so much bigger than the injectable one

PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses

tea also does not count, in case anyone was hoping
changed my mind on the plain water rule after reading how SNAC works, its not a formality

went back to injecting