vialroom

#oral-glp1 2025-01-29

Wednesday9 messages2 participantstimes are UTC
Highlights from this day
  • month_six_me — roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose 11:56
  • month_six_me — ok so PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses 12:48
  • month_six_me — does taking it with any food at all just waste the dose 13:19
  • month_six_me — the oral disappointed me on the mornings i couldnt manage 30 minutes fasted, which was most of them 13:20
MS

roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose

MS

lost 22kg over 14 months on oral, slower than my injectable stretch, i stuck with it anyway

PP

i was wrong about the water amount, i was using a sip and it needs a lot more than that

MS

ok so PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses

MS

does taking it with any food at all just waste the dose

🧪5🎉11👍3

the oral disappointed me on the mornings i couldnt manage 30 minutes fasted, which was most of them

Cited study
Oral Semaglutide 50 mg in Adults with Overweight or Obesity (OASIS 1)
The Lancet · 2023
The high-dose oral. Absorption rules matter enormously here.

did anyone find the oral easier on the gut than the injection

anyone switched from injectable to oral and kept the same effect

my weekly log on oral is noisier than my injectable log ever was, same scales same mornings