roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose
#oral-glp1 2025-02-11
Tuesday15 messages4 participantstimes are UTC
Highlights from this day
- vial_ledger — roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose 23:20
- vial_ledger — SNAC raises the local pH and protects it long enough to cross, thats its whole job, thats just me 23:22
- vial_ledger — i keep the tablet by the kettle so i take it before i think about food 23:25
- acetate_ash — orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ 23:27
- verify_or_dont — i said 26 months ago that my oral results were random, they got consistent once i fixed the water 23:39
SNAC raises the local pH and protects it long enough to cross, thats its whole job, thats just me
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one percent is the number people quote and the spread around it is the actual story
i keep the tablet by the kettle so i take it before i think about food
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the inconsistency is mostly technique and admitting that took me about a year
orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ
mine was patchy too
coffee doesnt count
plain water only
about one percent
anyone switched from injectable to oral and kept the same effect
i said 26 months ago that my oral results were random, they got consistent once i fixed the water
thirty minutes, no cheating
changed my mind on the plain water rule after reading how SNAC works, its not a formality
SNAC does the work