#oral-glp1 2025-02-21

Friday20 messages4 participantstimes are UTC

Highlights from this day

coa_or_cope — i do 6am with water and eat at 7, thats been my routine for 3 months 16:11
egfr_ed — PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses, thats one data point 16:54
egfr_ed — is the non peptide thing why orforglipron doesnt need the fasting rules 17:52

is orforglipron a peptide at all

does SNAC do anything other than get it through the stomach

lost 20kg over 3 months on oral, slower than my injectable stretch, i stuck with it anyway

OASIS ran under the same sort of fasting conditions, thats not the variable between the two

i do 6am with water and eat at 7, thats been my routine for 3 months

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PIONEER or OASIS, which one was the higher dose oral

went back to injecting

one percent is the number people quote and the spread around it is the actual story

back after 9 months, has anything changed on the oral side

took mine with breakfast once by accident and that week was a write off

right so the oral disappointed me on the mornings i couldnt manage 30 minutes fasted, which was most of them

PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses, thats one data point

orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ

sorry to jump in the fasting window is the difference between a dose and a very expensive tablet

PIONEER not OASIS

is the non peptide thing why orforglipron doesnt need the fasting rules

🔥2📈1✅11

is the plain water rule actually load bearing or is it a formality

does coffee count as plain water, asking for obvious reasons

oral was easier on my gut than injecting at what felt like a similar effect, which surprised me

i keep the tablet by the kettle so i take it before i think about food