the non peptide agents dose daily without the water ritual, thats the practical difference
#oral-glp1 2025-04-26
Saturday42 messages9 participantstimes are UTC
Highlights from this day
- cagri_curious — does coffee count as plain water, asking for obvious reasons 22:59
- cagri_curious — OASIS ran under the same sort of fasting conditions, thats not the variable between the two 23:03
- retention_time — my weekly log on oral is noisier than my injectable log ever was, same scales same mornings 23:08
- residual_solvent — roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose, for what its worth plain water only, about half a glass,… 23:21
not a peptide
did anyone get consistent results on the oral or is it always patchy
[edited]thirty minutes, no cheating
i do 6am with water and eat at 7, thats been my routine for 21 months
whats the bioavailability actually like, i keep seeing about one percent
is the non peptide thing why orforglipron doesnt need the fasting rules
coming back to this the inconsistency is mostly technique and admitting that took me about a year
22:16quiet.hours pinned a message
for the archive nobody should copy my morning routine, but the timer is the bit i would keep
coffee is not plain water. i tried it for a month and my results got worse
lost 40kg over 26 months on oral, slower than my injectable stretch, i stuck with it anyway
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is orforglipron a peptide at all
the fasting rule cost me my breakfast routine and thats the real reason people quit the oral
went back to injecting because the morning routine was too fragile around shift work
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the oral mg number is bigger because almost none of it gets in, thats the entire reason
changed my mind on the plain water rule after reading how SNAC works, its not a formality
SNAC does the work
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the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted
22:40quiet.hours pinned a message
does the 30 minutes start from swallowing or from the water
is the plain water rule actually load bearing or is it a formality
orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ, thats one data point
coffee doesnt count
ruined my breakfast
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i use it because needles are a genuine problem for me, not because i think its better
plain water only, about half a glass, then nothing for 30 minutes. i follow it exactly
does coffee count as plain water, asking for obvious reasons
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OASIS ran under the same sort of fasting conditions, thats not the variable between the two
unrelated but tea also does not count, in case anyone was hoping
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my weekly log on oral is noisier than my injectable log ever was, same scales same mornings
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anyone dosing oral because of a needle problem rather than preference
coming back to this is the inconsistency people report about the drug or about how they take it
right so does SNAC do anything other than get it through the stomach
went back to injecting
roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose, for what its worth
plain water only, about half a glass, then nothing for 30 minutes. i follow it exactly
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set a timer
23:27quiet.hours pinned a message to this channel
residual_solventroughly one percent gets absorbed, which is why the tablet strength looks nothing like…
PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses
fasted every morning
technique probably
splitting a dose made the absorption problem worse rather than better in my own log
[edited]