vialroom

#oral-glp1 2025-05-31

Saturday19 messages6 participantstimes are UTC
Highlights from this day
  • appetite_back — SNAC raises the local pH and protects it long enough to cross, thats its whole job 18:54
  • VialBot — Inter-lab diff for lot SG-1177: 99.2% vs 96.8%. Within expected range. 19:13
  • appetite_back — took 22 weeks before i saw anything on oral, roughly twice what the injection took me 19:30
  • bea_reconstitutes — i was wrong about the water amount, i was using a sip and it needs a lot more than that 20:36
AB

SNAC raises the local pH and protects it long enough to cross, thats its whole job

🔥18🎉8
VB

Inter-lab diff for lot SG-1177: 99.2% vs 96.8%. Within expected range.

AB

took 22 weeks before i saw anything on oral, roughly twice what the injection took me

Cited study
Oral Semaglutide 50 mg in Adults with Overweight or Obesity (OASIS 1)
The Lancet · 2023
The high-dose oral. Absorption rules matter enormously here.

why does the same tablet do different things week to week

BR

roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose

LA

my weekly log on oral is noisier than my injectable log ever was, same scales same mornings

LA

i said 2 months ago that my oral results were random, they got consistent once i fixed the water

the fasting window is the difference between a dose and a very expensive tablet

*Janoshik not the other one

LA

took mine with breakfast once by accident and that week was a write off

tea also does not count, in case anyone was hoping

MS

i use it because needles are a genuine problem for me, not because i think its better
my weekly log on oral is noisier than my injectable log ever was, same scales same mornings