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#oral-glp1 2025-07-07

Monday31 messages7 participantstimes are UTC
Highlights from this day
  • seizure_letter — orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ, ill dig out the number 12:45
  • seizure_letter — is orforglipron a peptide at all 12:46
  • thirty_min_wait — does the 30 minutes start from swallowing or from the water 13:36
  • per_mg_pete — i do 6am with water and eat at 7, thats been my routine for 1 months 13:58
  • cagri_curious — is the plain water rule actually load bearing or is it a formality my oral results were inconsistent week to week and i eventually decided it was me, not the tablet 14:22

orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ, ill dig out the number

👀11

is orforglipron a peptide at all

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SNAC does the work

is the non peptide thing why orforglipron doesnt need the fasting rules

my oral results were inconsistent week to week and i eventually decided it was me, not the tablet

PIONEER not OASIS

PM

switched from injectable to oral, lost some of the effect, switched back after 8 months, i could be wrong

[edited]

the non peptide agents dose daily without the water ritual, thats the practical difference

TF

changed my mind on the plain water rule after reading how SNAC works, its not a formality

PM

i do 6am with water and eat at 7, thats been my routine for 1 months

⚠️18🙏1

the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted
changed my mind on the plain water rule after reading how SNAC works, its not a formality

does SNAC do anything other than get it through the stomach

thirty minutes, no cheating

went back to injecting

Cited study
Oral Semaglutide 50 mg in Adults with Overweight or Obesity (OASIS 1)
The Lancet · 2023
The high-dose oral. Absorption rules matter enormously here.

coffee doesnt count

CC

is the plain water rule actually load bearing or is it a formality
my oral results were inconsistent week to week and i eventually decided it was me, not the tablet

coa-kp-0925.pdf
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📈1
TT

lost 22kg over 13 months on oral, slower than my injectable stretch, i stuck with it anyway