whats the bioavailability actually like, i keep seeing about one percent
i do 6am with water and eat at 7, thats been my routine for 26 months
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#oral-glp1 2025-10-04
Saturday28 messages7 participantstimes are UTC
Highlights from this day
- salt_bridge — whats the bioavailability actually like, i keep seeing about one percent i do 6am with water and eat at 7, thats been my routine for 26 months 15:25
- salt_bridge — did anyone go back to injecting after trying oral 16:21
- noct.titrate — quick one PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses 16:52
- noct.titrate — went back to injecting because the morning routine was too fragile around shift work 18:45
- secretagogue_sy — my weekly log on oral is noisier than my injectable log ever was, same scales same mornings 19:03
for the archive why is the oral dose in mg so much bigger than the injectable one
big mg small dose
nobody should copy my morning routine, but the timer is the bit i would keep
oral was easier on my gut than injecting at what felt like a similar effect, which surprised me
coffee doesnt count
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i said 1 months ago that my oral results were random, they got consistent once i fixed the water
lost 33kg over 25 months on oral, slower than my injectable stretch, i stuck with it anyway
OASIS ran under the same sort of fasting conditions, thats not the variable between the two
did anyone go back to injecting after trying oral
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SNAC raises the local pH and protects it long enough to cross, thats its whole job
took 26 weeks before i saw anything on oral, roughly twice what the injection took me, your mileage will differ
follow up tea also does not count, in case anyone was hoping
quick one PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses
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PIONEER or OASIS, which one was the higher dose oral
anyone switched from injectable to oral and kept the same effect
coffee is not plain water. i tried it for a month and my results got worse
the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted
technique probably
oral was easier on my gut than injecting at what felt like a similar effect, which surprised me
SNAC does the work
does taking it with any food at all just waste the dose
i use it because needles are a genuine problem for me, not because i think its better
went back to injecting because the morning routine was too fragile around shift work
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while im here i keep the tablet by the kettle so i take it before i think about food
auckland_aliquotthe 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted
how strict is the 30 minute wait before food for people here
switched from injectable to oral, lost some of the effect, switched back after 18 months
coffee is not plain water. i tried it for a month and my results got worse
my weekly log on oral is noisier than my injectable log ever was, same scales same mornings
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the oral mg number is bigger because almost none of it gets in, thats the entire reason
roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose