mine was patchy too
#oral-glp1 2025-12-10
Wednesday35 messages7 participantstimes are UTC
Highlights from this day
- luerlok — my oral results were inconsistent week to week and i eventually decided it was me, not the tablet 20:48
- subq_sy — orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ 21:11
- plateau_pen — genuine question is the absorption variability why the oral doses look so high 23:04
the fasting window is the difference between a dose and a very expensive tablet
did anyone get consistent results on the oral or is it always patchy
how strict is the 30 minute wait before food for people here
back after 8 months, has anything changed on the oral side
is orforglipron a peptide at all
technique probably
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switched from injectable to oral, lost some of the effect, switched back after 5 months
not a peptide
does coffee count as plain water, asking for obvious reasons
ruined my breakfast
follow up did anyone go back to injecting after trying oral
is there any point splitting an oral dose
SNAC does the work
tea also does not count, in case anyone was hoping
splitting a dose made the absorption problem worse rather than better in my own log
coffee is not plain water. i tried it for a month and my results got worse
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sorry to jump in nobody should copy my morning routine, but the timer is the bit i would keep
thirty minutes, no cheating
my oral results were inconsistent week to week and i eventually decided it was me, not the tablet
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unrelated but roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose
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the oral mg number is bigger because almost none of it gets in, thats the entire reason
orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ
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the fasting rule cost me my breakfast routine and thats the real reason people quit the oral
the oral disappointed me on the mornings i couldnt manage 30 minutes fasted, which was most of them, n of 1 obviously
PIONEER not OASIS
does taking it with any food at all just waste the dose
absorption is the variable, not the molecule. same tablet, different morning, different result
*Medutest not the other one
i keep the tablet by the kettle so i take it before i think about food
coming back to this lost 23kg over 22 months on oral, slower than my injectable stretch, i stuck with it anyway
i said 17 months ago that my oral results were random, they got consistent once i fixed the water
plain water only, about half a glass, then nothing for 30 minutes. i follow it exactly
went back to injecting because the morning routine was too fragile around shift work
genuine question is the absorption variability why the oral doses look so high
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oral was easier on my gut than injecting at what felt like a similar effect, which surprised me
nobody should copy my morning routine, but the timer is the bit i would keep