plain water only
#oral-glp1 2026-01-21
Wednesday44 messages9 participantstimes are UTC
Highlights from this day
ruined my breakfast
the non peptide orals are the interesting part of this channel now, not oral semaglutide
the non peptide agents dose daily without the water ritual, thats the practical difference
anyone switched from injectable to oral and kept the same effect
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coming back to this i keep the tablet by the kettle so i take it before i think about food, i think
thirty minutes, no cheating
does SNAC do anything other than get it through the stomach
why is the oral dose in mg so much bigger than the injectable one
PIONEER not OASIS
quick one one percent is the number people quote and the spread around it is the actual story
went back to injecting
went back to injecting because the morning routine was too fragile around shift work
PIONEER or OASIS, which one was the higher dose oral
my oral results were inconsistent week to week and i eventually decided it was me, not the tablet
the inconsistency is mostly technique and admitting that took me about a year
the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted
does the 30 minutes start from swallowing or from the water
about one percent
tea also does not count, in case anyone was hoping
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i was wrong about the water amount, i was using a sip and it needs a lot more than that
is there any point splitting an oral dose
anyone dosing oral because of a needle problem rather than preference
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coffee is not plain water. i tried it for a month and my results got worse, for what its worth
lost 36kg over 7 months on oral, slower than my injectable stretch, i stuck with it anyway
[edited]i said 3 months ago that my oral results were random, they got consistent once i fixed the water
i use it because needles are a genuine problem for me, not because i think its better
why does the same tablet do different things week to week
is the plain water rule actually load bearing or is it a formality
the fasting rule cost me my breakfast routine and thats the real reason people quit the oral
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does taking it with any food at all just waste the dose
is orforglipron a peptide at all
splitting a dose made the absorption problem worse rather than better in my own log
not a peptide
OASIS ran under the same sort of fasting conditions, thats not the variable between the two
the inconsistency is mostly technique and admitting that took me about a year
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absorption is the variable, not the molecule. same tablet, different morning, different result
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PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses
follow up orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ
did anyone get consistent results on the oral or is it always patchy
i keep the tablet by the kettle so i take it before i think about food
coming back to this anyone tracking whether their oral results line up week to week
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did OASIS use the same fasting conditions as the earlier work
coffee doesnt count
oral was easier on my gut than injecting at what felt like a similar effect, which surprised me