i was wrong about the water amount, i was using a sip and it needs a lot more than that
#oral-glp1 2026-02-26
Thursday21 messages6 participantstimes are UTC
Highlights from this day
- point_two_five — is orforglipron a peptide at all 14:33
- void_volume — follow up how much water exactly, is it a small sip or half a glass 14:37
- point_two_five — the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted 15:48
- no_appetite_nia — coming back to this does SNAC do anything other than get it through the stomach 16:50
- adelaide_assay — switched from injectable to oral, lost some of the effect, switched back after 15 months the oral mg number is bigger because almost none of it gets in, thats the… 16:56
is orforglipron a peptide at all
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i use it because needles are a genuine problem for me, not because i think its better, i could be wrong
follow up how much water exactly, is it a small sip or half a glass
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mine was patchy too
i said 20 months ago that my oral results were random, they got consistent once i fixed the water
splitting a dose made the absorption problem worse rather than better in my own log
hair_month_fouri was wrong about the water amount, i was using a sip and it needs a lot more than that
the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted
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SNAC does the work
coming back to this does SNAC do anything other than get it through the stomach
weights-monthly.csv
508 rows · not retained in the public archive
lost 13kg over 3 months on oral, slower than my injectable stretch, i stuck with it anyway
hair_month_fouri was wrong about the water amount, i was using a sip and it needs a lot more than that
switched from injectable to oral, lost some of the effect, switched back after 15 months
the oral mg number is bigger because almost none of it gets in, thats the entire reason
the fasting window is the difference between a dose and a very expensive tablet
orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ
took 30 weeks before i saw anything on oral, roughly twice what the injection took me, ymmv
coffee doesnt count
did OASIS use the same fasting conditions as the earlier work
one percent is the number people quote and the spread around it is the actual story, i could be wrong
genuine question the oral disappointed me on the mornings i couldnt manage 30 minutes fasted, which was most of them
why is the oral dose in mg so much bigger than the injectable one