absorption is the variable, not the molecule. same tablet, different morning, different result
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#oral-glp1 2026-04-30
Thursday24 messages4 participantstimes are UTC
Highlights from this day
- batch_variance — absorption is the variable, not the molecule. same tablet, different morning, different result 18:00
- batch_variance — why does the same tablet do different things week to week 18:20
- batch_variance — the fasting rule cost me my breakfast routine and thats the real reason people quit the oral my weekly log on oral is noisier than my injectable log ever was, same… 18:29
- glasgow_vial — right so OASIS ran under the same sort of fasting conditions, thats not the variable between the two 18:49
- nettle_notes — while im here changed my mind on the plain water rule after reading how SNAC works, its not a formality 19:52
*Janoshik not the other one
whats the bioavailability actually like, i keep seeing about one percent
my oral results were inconsistent week to week and i eventually decided it was me, not the tablet
why does the same tablet do different things week to week
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PIONEER not OASIS
fasted every morning
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the fasting rule cost me my breakfast routine and thats the real reason people quit the oral
my weekly log on oral is noisier than my injectable log ever was, same scales same mornings
coffee is not plain water. i tried it for a month and my results got worse
went back to injecting
PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses
anyone switched from injectable to oral and kept the same effect
right so OASIS ran under the same sort of fasting conditions, thats not the variable between the two
is the inconsistency people report about the drug or about how they take it
is the non peptide thing why orforglipron doesnt need the fasting rules
how long before the oral did anything measurable for you
not a peptide
i do 6am with water and eat at 7, thats been my routine for 5 months, ymmv
i keep the tablet by the kettle so i take it before i think about food
while im here changed my mind on the plain water rule after reading how SNAC works, its not a formality
took mine with breakfast once by accident and that week was a write off
i was wrong about the water amount, i was using a sip and it needs a lot more than that
SNAC raises the local pH and protects it long enough to cross, thats its whole job
coffee doesnt count