splitting a dose made the absorption problem worse rather than better in my own log
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#oral-glp1 2026-06-28
Sunday25 messages6 participantstimes are UTC
Highlights from this day
- egfr_ed — splitting a dose made the absorption problem worse rather than better in my own log 19:18
- apob_over_ldl — while im here nobody should copy my morning routine, but the timer is the bit i would keep 19:21
- apob_over_ldl — switched from injectable to oral, lost some of the effect, switched back after 16 months, thats just me 19:49
- area_percent — plain water only, about half a glass, then nothing for 30 minutes. i follow it exactly 19:57
- ivy_injects — did anyone find the oral easier on the gut than the injection 20:21
i use it because needles are a genuine problem for me, not because i think its better
while im here nobody should copy my morning routine, but the timer is the bit i would keep
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slightly off topic but tea also does not count, in case anyone was hoping, thats one data point
absorption is the variable, not the molecule. same tablet, different morning, different result
is the absorption variability why the oral doses look so high
PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses
switched from injectable to oral, lost some of the effect, switched back after 16 months, thats just me
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my oral results were inconsistent week to week and i eventually decided it was me, not the tablet
fasted every morning
plain water only, about half a glass, then nothing for 30 minutes. i follow it exactly
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follow up lost 36kg over 12 months on oral, slower than my injectable stretch, i stuck with it anyway
mine was patchy too
how long before the oral did anything measurable for you
is orforglipron a peptide at all
sorry to jump in the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted
did OASIS use the same fasting conditions as the earlier work
went back to injecting
technique probably
did anyone find the oral easier on the gut than the injection
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i said 5 months ago that my oral results were random, they got consistent once i fixed the water
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SNAC does the work
coa-e-2205.pdf
1 page · 242 KB · not retained in the public archive
PIONEER not OASIS
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is the plain water rule actually load bearing or is it a formality
coffee doesnt count
plain water only