research use only
Thread · #oral-glp1 · 2025-07-14
is PIONEER the right programme to be quoting
Spun off from a message in #oral-glp1 on 2025-07-14. 12 messages, 2 participants.
The message this came from
- thirty_one_g — is PIONEER the right programme to be quoting for this 22:36
oh wow, big mg small dose
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small molecule, different rules
storage for orals is a dry, room temperature problem rather than a cold chain one
small molecule, so lost 12kg over 13 months on oral, slower than my injectable stretch, i stuck with it anyway
absorption thing plain water, a small sip, and then nothing for half an hour. every deviation i made showed up, that is the studied protocol
more water than the small sip is a deviation and i would not assume it is harmless to absorption, nothing here is advice
on the small molecule side how strict is strict about the water being plain
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one percent is the number people quote and the spread around it is the actual story
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absorption thing is the plain water rule actually load bearing or is it a formality
tablet storage question this is research use material and the protocol is the thing that makes it work at all, orforglipron is a small molecule, different rules
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PIONEER is the programme people mean when they quote numbers here and it is worth naming which one