slightly off topic but is there any reason not to just always use 2ml
#reconstitution 2025-10-26
Sunday59 messages12 participantstimes are UTC
Highlights from this day
- retention_time — coming back after 9 months, has the pinned recon volume advice changed 00:52
- panel_before_after — i was wrong about this last year: it is fine to draw cold, it just stings more going in 07:42
- panel_before_after — temperature of the diluent does not matter. how fast you push it in does 07:45
- fridge_thermo — for the archive im getting bubbles in the barrel every single time, what am i doing wrong 08:11
- reship_rita — dead space in a standard insulin syringe hub is small but it is not nothing over a month 09:15
dead space
update from 19 months ago: switched to a single concentration and have not miscalculated since
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coming back after 9 months, has the pinned recon volume advice changed
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yep 10 units
5mg in 2ml gives 2.5mg/ml, 0.25mg is 10 units. good for a starting dose
bacteriostatic water for anything multi-use. sterile water has no preservative in it at all
you can absolutely just always use 2ml, and honestly most of us should
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thats the vacuum
do you draw up with the same pin you inject with
swirl dont shake
thats fine
i write the mg/ml on the vial with a sharpie the moment i reconstitute it
took me a year to stop over-diluting. the measurement error at 4 units is worse than the convenience
a slightly collapsed cake is cosmetic. a puddle in the bottom is not
dead space in a standard insulin syringe hub is small but it is not nothing over a month
the powder is stuck to the stopper, do i care
weighing the vial before you reconstitute is the only way to catch an underfill
whats the smallest volume you would trust yourself to measure on a u100
10mg in 2ml is 5mg/ml. so 0.5mg is 0.1ml which is 10 units on a u100
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what do you do with the last 20 units when you cant draw them cleanly
nobody here should be telling you a dose. we can check your arithmetic, thats a different thing
clear or bin it
my vial pulled the water in on its own, is that the vacuum or did i do something
15mg in 3ml is 5mg/ml. same numbers as 10 in 2, just more of it
if i add 0.5ml to a 5mg vial what concentration am i actually at
is a slightly cloudy solution ever ok or is that always a bin it
10mg in 1ml is 10mg/ml, so 2.5mg is 25 units. thats the one i use
if you cannot read the mark confidently, your volume is too small. redo it at a lower concentration
how much do i lose to dead space with a 31G pin
do you let it come to room temp before drawing or draw it cold
follow up do not add more bac water to an already reconstituted vial, you have lost track of the concentration
my rule is one concentration for everything so i never have to think about it at 7am, thats one data point
the meniscus thing is real. read it at eye level or you are guessing by a unit either way
aim the diluent at the glass wall, not at the powder. it goes in gentler
write the date on
i swirl for about thirty seconds and then leave it. never had one fail to dissolve
bac water
swirl it. do not shake it. the foam is denatured protein and you are not getting it back
i have never once regretted using a rounder number and a slightly bigger volume
thats 5mg/ml
i was wrong about this last year: it is fine to draw cold, it just stings more going in
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temperature of the diluent does not matter. how fast you push it in does
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label the vial
the vacuum will pull it in. let it. fighting it is how you get a face full of aerosol
read it at eye level
i use bac water even for a single-use vial because it stings less, which is not the reason it exists
for the archive im getting bubbles in the barrel every single time, what am i doing wrong
10mg vial
+ 1.0ml -> 10.0 mg/ml 0.5mg = 5u 1mg = 10u
+ 2.0ml -> 5.0 mg/ml 0.5mg = 10u 1mg = 20u
+ 2.5ml -> 4.0 mg/ml 0.5mg = 12.5u (dont)
+ 5.0ml -> 2.0 mg/ml 0.5mg = 25u 1mg = 50unot sterile water
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pick the volume so your dose is a whole number of units. thats the entire trick
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does temperature of the bac water matter at all
round numbers
do i swirl for a specific length of time or just until its clear
check your maths
benzyl alcohol is what makes it bacteriostatic. it is about 0.9% typically, ill dig out the number
i swirl for about thirty seconds and then leave it. never had one fail to dissolve
genuine question check your maths
anyone else find the 10mg vials harder to get fully dissolved than the small ones
weigh it first
dead space in a standard insulin syringe hub is small but it is not nothing over a month
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30mg in 3ml is 10mg/ml, so 5mg is 50 units. half the barrel, feels like a lot but its right