vialroom

#retatrutide 2025-03-22

Saturday24 messages6 participantstimes are UTC
Highlights from this day
  • first_month_fi — the heart rate thing is real enough that i mention it whenever someone asks about starting, ill dig out the number 14:32
  • dose_day_drift — i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind 14:40
  • dose_day_drift — TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no… 14:49
  • dose_day_drift — triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history 14:57
  • lot_number_lou — my resting heart rate is up about 8 bpm, did that settle for anyone 18:12
FM

the heart rate thing is real enough that i mention it whenever someone asks about starting, ill dig out the number

👍12🔥1🙏18
DD

i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind

Cited study
Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
New England Journal of Medicine · 2023
48 weeks, dose-ranging. A Phase 2 result is not a safety record.
DD

TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history

[edited]
DD

triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history

😂4📈1🧪17
MO

stopped for 25 months and restarted at half my old dose, the ramp was easier second time

MO

genuine question the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me

FN

coming back to this does the glucagon arm explain the heart rate or is that unrelated

MO

no idea whether the heart rate settles for everyone, mine did and one log isnt data

DD

update on the earlier thing how do people square the research use only framing with logging their own use

no long term data

LN

i log resting heart rate every morning because of this and its the one number i actually watch

DD

did anyone come off because of the heart rate
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom

DD

i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps, ymmv

TRIUMPH is phase 3

👀4
LN

sorry to jump in my resting rate went up 8 bpm in the first month and came back most of the way by month 9

my resting heart rate is up about 8 bpm, did that settle for anyone

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A1

anyone tracking blood pressure alongside the heart rate